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Our laboratory demonstrated that SERT and αvβthree receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβ3 in midbrain synapses. Former scientific studies recommend that in platelets, the Affiliation of SERT with activated αIIbβ3 integrins, and its localization to adhesion complexes, are correlated with greater uptake exercise (Carneiro et al.
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The context-dependent character of SERT regulation is underscored from the lack of colocalization of SERT with focal adhesion proteins in KI synapses. This means the Affiliation of SERT with integrin signaling complexes is just not needed for the regulation in the transporter by constitutive signaling downstream of the “primed” Pro32Pro33 mutant.
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